Bis-isopropyl-PEG1

Names

[ Name ]:
Bis-isopropyl-PEG1

[Synonym ]:
1,2-Diisopropoxy-aethan
2-(2-isopropoxyethoxy)propane
2,2'-[ETHYLENEBIS(OXY)]BISPROPANE
1,2-diisopropoxy-ethane
EINECS 223-532-7

Biological Activity

[Description]:

Bis-isopropyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
0.84g/cm3

[ Boiling Point ]:
148.2ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₈O₂

[ Molecular Weight ]:
146.22700

[ Flash Point ]:
26ºC

[ Exact Mass ]:
146.13100

[ PSA ]:
18.46000

[ LogP ]:
1.83640

[ Index of Refraction ]:
1.403

Safety Information

[ HS Code ]:
2909199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%