Elastase from porcine pancreas

Names

[ Name ]:
Elastase from porcine pancreas

[Synonym ]:
MFCD00130998
EINECS 254-453-6

Biological Activity

[Description]:

Elastase from porcine pancreas is a single polypeptide chain of 240 amino acid residues. Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Elastase from porcine pancreas induces emphysema in hamsters[3].

[References]

[1]. Shotton DM, et, al. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases. Nature. 1970 Feb 28;225(5235):802-6.

[2]. Teshima T, et, al. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates. J Biol Chem. 1982 May 10;257(9):5085-91.

[3]. Stone PJ, et, al. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid. Am Rev Respir Dis. 1990 Jan;141(1):47-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₁N₄O₇Cl

[ Molecular Weight ]:
474.93574

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger, Warning

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R42;R36/37/38

[ Safety Phrases ]:
S22;S24;S26;S36/S37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Preparation

Articles

Targeting latent TGFβ release in muscular dystrophy.

Sci. Transl. Med. 6(259) , 259ra144, (2014)

Latent transforming growth factor-β (TGFβ) binding proteins (LTBPs) bind to inactive TGFβ in the extracellular matrix. In mice, muscular dystrophy symptoms are intensified by a genetic polymorphism th...

Can we predict postoperative pancreatic leakage after pancreaticoduodenectomy using preoperative fecal elastase-1 level?

J. Clin. Lab Anal. 27(5) , 379-83, (2013)

The measurement of fecal elastas-1 in stools is a sensitive and relatively inexpensive noninvasive test. The aim of this study was to study fecal elastase levels in patients who develop pancreatic lea...

Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema.

PLoS ONE 10 , e0129590, (2015)

To describe the progression of parenchymal remodeling and metalloproteinases gene expression in earlier stages of emphysema, mice received porcine pancreatic elastase (PPE) instillation and Control gr...