Cupressuflavone

Names

[ Name ]:
Cupressuflavone

[Synonym ]:
8-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
8,8'-Biapigenin
Cupressuflavone

Biological Activity

[Description]:

Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Cupressuflavone (40-160 mg/kg; p.o. once daily for 5 days) 在肝脏和肾脏组织中通过增强抗氧化防御状态、减少脂质过氧化和防止 CCl4 诱导的病理变化来对抗氧化应激[1]。 Cupressuflavone (40-160 mg/kg; p.o.) 在40, 100, 160 mg/kg 剂量下分别抑制角叉菜胶诱导的炎症爪水肿 55%、60% 和 64%[2]。

[References]

[1]. Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71.

[2]. Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28.

[3]. Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34.

Chemical & Physical Properties

[ Boiling Point ]:
1083.4ºC at 760mmHg

[ Melting Point ]:
>400ºC

[ Molecular Formula ]:
C₃₀H₁₈O₁₀

[ Molecular Weight ]:
538.46

[ Flash Point ]:
609ºC

[ Exact Mass ]:
538.09000

[ PSA ]:
181.80000

[ LogP ]:
5.13400

[ Index of Refraction ]:
1.793