benzotript

Names

[ Name ]:
benzotript

[Synonym ]:
N-carbamothioyl-4-chloro-benzamide
EINECS 254-500-0
N-p-Chlorbenzoyl-thioharnstoff
(4-chloro-benzoyl)-thiourea
N-p-chlorobenzoyl-L-tryptophane
N-(4-chlorobenzoyl)-L-tryptophan

Biological Activity

[Description]:

Benzotript (Benzotriptum) is a cholecystokinin-receptor (CCK) and gastrin receptor antagonist. Benzotript shows antiproliferative effects in human colon carcinoma cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. N M Hoosein, et al. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res. 1988 Dec 15;48(24 Pt 1):7179-83.

[2]. C Niederau, et al. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985 May;88(5 Pt 1):1192-204.

Chemical & Physical Properties

[ Boiling Point ]:
643.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₅ClN₂O₃

[ Molecular Weight ]:
342.78

[ Flash Point ]:
343.1ºC

[ Exact Mass ]:
342.07700

[ PSA ]:
82.19000

[ LogP ]:
3.63790

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%