rosoxacin

Names

[ Name ]:
rosoxacin

[Synonym ]:
Rosoxacinum
Eracine
1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid
1,4-Dihydro-1-ethyl-7-(4-pyridinyl)-4-oxo-3quinolinecarboxylic acid
Rosoxacino
Roxadyl
Eradacin
Eradacil
Rosoxacine
Acrosoxacin
ROSOXACIN
1-ethyl-1,4-dihydro-4-oxo-7-(pyridin-4-yl)-3-quinolinecarboxylic acid
Winuron
1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinoxalinecarboxylic acid

Biological Activity

[Description]:

Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC90=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC90: 0.03 mg/ml[1]

[References]

[1]. Lim KB, et al. Treatment of uncomplicated gonorrhoea with rosoxacin (acrosoxacin).Br J Vener Dis. 1984 Jun;60(3):157-60.

Chemical & Physical Properties

[ Density]:
1.317g/cm3

[ Boiling Point ]:
500.8ºC at 760 mmHg

[ Melting Point ]:
290°

[ Molecular Formula ]:
C₁₇H₁₄N₂O₃

[ Molecular Weight ]:
294.30500

[ Flash Point ]:
256.7ºC

[ Exact Mass ]:
294.10000

[ PSA ]:
72.19000

[ LogP ]:
2.78160

[ Index of Refraction ]:
1.633

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%