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Andarine

Names

[ CAS No. ]:
401900-40-1

[ Name ]:
Andarine

[Synonym ]:
(S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide
S-3-(4-Acetylamino-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
(2S)-3-(4-Acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Andarine
Propanamide, 3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-, (2S)-
(S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide)
UNII-7UT2HAH49H
Ostarine
S4
GTX007
S1140_Selleck
MK-2866

Biological Activity

[Description]:

Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist.

[Related Catalog]:

Signaling Pathways >> Others >> Androgen Receptor
Research Areas >> Cancer

[References]

[1]. Thevis M, Geyer H, Kamber M, Sch?nzer W.Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product.Drug Test Anal. 2009 Aug;1(8):387-92.

[2]. Thevis M, Thomas A, Fussh?ller G, Beuck S, Geyer H, Sch?nzer W.Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes.Rapid Commun Mass Spectrom. 2010 Aug

[3]. Thomas A, Geyer H, Sch?nzer W, Crone C, Kellmann M, Moehring T, Thevis M.Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer.Anal Bioanal Chem. 2012 May;40

[4]. Guddat S, Solymos E, Orlovius A, Thomas A, Sigmund G, Geyer H, Thevis M, Sch?nzer W.High-throughput screening for various classes of doping agents using a new 'dilute-and-shoot' liquid chromatography-tandem mass spectrometry multi-target approach.Drug Tes

[5]. Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005 Jun;5(3):173-88.


[Related Small Molecules]

ARN-509 | Dehydroepiandrosterone | Flutamide | ODM-201 | Danazol | 3,3'-Diindolylmethane | AZD3514 | RAD140 | BMS-564929 | GLPG0492 | Cyproterone acetate | LGD-4033 | Lupeol | MK-0773 | ORM-15341

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
698.7±55.0 °C at 760 mmHg

[ Melting Point ]:
70-74ºC

[ Molecular Formula ]:
C19H18F3N3O6

[ Molecular Weight ]:
441.358

[ Flash Point ]:
376.4±31.5 °C

[ Exact Mass ]:
441.114777

[ PSA ]:
133.48000

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Related Compounds