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SB-399885

Names

[ CAS No. ]:
402713-80-8

[ Name ]:
SB-399885

[Synonym ]:
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(piperazin-1-yl)benzenesulfonamide
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide
Benzenesulfonamide, N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-

Biological Activity

[Description]:

SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT6 Receptor:9.02 (pKi)

Human 5-HT6 Receptor:9.11 (pKi)


[References]

[1]. Warren D Hirst, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H21Cl2N3O4S

[ Molecular Weight ]:
446.34800

[ Exact Mass ]:
445.06300

[ PSA ]:
88.28000

[ LogP ]:
4.76860

Related Compounds