Tyrosine, 3-fluoro-

Names

[ CAS No. ]:
403-90-7

[ Name ]:
Tyrosine, 3-fluoro-

[Synonym ]:
2-Amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid
MFCD00063075
FLUORTHYRIN
PARDINON
DL-M-FLUOROTYROSINE
ba2745
DL-3-FLUOROTYROSINE
m-fluorotyrosine
m-ftyr
H-3-FLUORO-DL-TYR-OH
EINECS 206-964-0
3-FLUORO-TYROSINE
Tyrosine, 3-fluoro-
rac-3-Fluorotyrosine
M-FLUORO-DL-TYROSINE
3'-fluoro-DL-tyrosine

Biological Activity

[Description]:

2-Amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid is a tyrosine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.421g/cm3

[ Boiling Point ]:
362.4ºC at 760mmHg

[ Melting Point ]:
276-280ºC

[ Molecular Formula ]:
C₉H₁₀FNO₃

[ Molecular Weight ]:
199.17900

[ Flash Point ]:
172.9ºC

[ Exact Mass ]:
199.06400

[ PSA ]:
83.55000

[ LogP ]:
1.18600

[ Vapour Pressure ]:
6.94E-06mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong reducing agents, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2660000

CHEMICAL NAME :: Tyrosine, 3-fluoro-, DL-

CAS REGISTRY NUMBER :: 403-90-7

BEILSTEIN REFERENCE NO. :: 3204804

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-N-O3

MOLECULAR WEIGHT :: 199.20

WISWESSER LINE NOTATION :: QVYZ1R DQ CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 68,1671,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 155,135,1967

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,T

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN 3276

[ WGK Germany ]:
3

[ RTECS ]:
YP2660000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase.

Biochemistry 45(31) , 9575-83, (2006)

Tyrosine phenol-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the reversible hydrolytic cleavage of l-Tyr to give phenol and ammonium pyruvate...

Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.

Biophys. J. 89(6) , 4171-9, (2005)

Incorporation of 3-fluorotyrosine and site-specific mutagenesis has been utilized with Fourier transform infrared (FTIR) spectroscopy and x-ray crystallography to elucidate active-site structure and t...

Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine.

J. Mol. Biol. 281(2) , 323-39, (1998)

The structure of the tetradeca-(3-fluorotyrosyl) M1-1 GSH transferase (3-FTyr GSH transferase), a protein in which tyrosine residues are globally substituted by 3-fluorotyrosines has been determined a...