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15-Keto Travoprost

Names

[ CAS No. ]:
404830-45-1

[ Name ]:
15-Keto Travoprost

[Synonym ]:
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
Travoprost impurity,15-keto derivative-[USP]
UNII-4U2P9U9Z66
Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}cyclopentyl]-5-heptenoate
15-Oxo travoprost
15-keto Fluprostenol isopropyl ester
15-Keto Travoprost
(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
(5Z,13E)-(9S,11R)-9,11,-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid,isopropyl ester

Biological Activity

[Description]:

15-Keto Travoprost (15-Keto Fluprostenol isopropyl ester) is a metabolite of Travoprost (HY-B0584). 15-Keto Travoprost shows stimulatory effect on the growth and thickening of the eyelashes[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

15-Keto Travoprost (80 µgr/mL) can be used for the treatment of idiopathic hypotrichosis of the eyelashes[1].

[References]

[1]. Fabbrocini G, et al. 15 keto fluprostenol isopropyl ester (80 µgr/mL) gel for cosmetic eyelash growth and enhancement. J Cosmet Dermatol. 2019 Apr;18(2):545-549.

[2]. Ciro C, et al. Effect of Fluprostenol Isopropyl Ester and 15-Keto Fluprostenol on Eyelash Growth: A Clinical and Pharmacologic Study. Skinmed. 2018 Jul 1;16(4):231-233.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
577.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H33F3O6

[ Molecular Weight ]:
498.532

[ Flash Point ]:
303.1±30.1 °C

[ Exact Mass ]:
498.222931

[ PSA ]:
93.06000

[ LogP ]:
3.82

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.541

Related Compounds