guanadrel

Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.

[1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x.