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TLR4-IN-C34

Names

[ CAS No. ]:
40592-88-9

[ Name ]:
TLR4-IN-C34

[Synonym ]:
α-D-Glucopyranoside, 1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate
Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
MFCD28053519
TLR4-IN-C34

Biological Activity

[Description]:

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

[In Vivo]

TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa[1]. Animal Model: Experimental NEC induced in 7-8 day old mice[1]. Dosage: 1 mg/kg. Administration: Orally every morning. Result: Attenuated intestinal inflammation.

[References]

[1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.

[2]. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
519.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H27NO9

[ Molecular Weight ]:
389.398

[ Flash Point ]:
268.2±30.1 °C

[ Exact Mass ]:
389.168579

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.484

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds