Isoviolanthin

Names

[ Name ]:
Isoviolanthin

[Synonym ]:
5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-6-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yl)-chromen-4-one

Biological Activity

[Description]:

Isoviolanthin is a flavonoid glycoside extracted from the leaves of Dendrobium officinale. Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells but exhibits no cytotoxic effects on normal live cells, and has potential as a therapeutic agent for the treatment of advanced-stage metastatic HCC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₀O₁₄

[ Molecular Weight ]:
578.51900

[ Exact Mass ]:
578.16400

[ PSA ]:
250.97000

Safety Information

[ Hazard Codes ]:
Xi