H-Tyr-OEt·HCl

Names

[ Name ]:
H-Tyr-OEt·HCl

[Synonym ]:
L-Tyrosine Ethyl Ester Hydrochloride
Ethyl L-tyrosinate hydrochloride (1:1)
Tyrosine, ethyl ester, hydrochloride, L-
tyrosineethylesterhydrochloride
Tyr-Oet Hcl
EthylL-tyrosinatehydrochloride
EINECS 223-820-2
L-Tyrosine ethyl est
H-Tyr-OEt HCl
L-Tyr-OEt.HCL
TEE
L-Tyrosine, ethyl ester, hydrochloride (1:1)
H-Tyr-OEt·HCl
MFCD00063047
L-Tyrosine, ethyl ester, hydrochloride
L-TYROSINE ETHYL ESTER HCL
H-L-Tyr-OEt*HCl
H-Tyr-Oet.Hcl
L-tyrosine ethyl ester monohydrochloride
DL-tyrosine ethyl ester hydrochloride
TYROSINE-OET HCL

Biological Activity

[Description]:

H-Tyr-OEt.HCl is a tyrosine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.177 g/cm3

[ Boiling Point ]:
343.3ºC at 760 mmHg

[ Melting Point ]:
166-170 °C

[ Molecular Formula ]:
C₁₁H₁₆ClNO₃

[ Molecular Weight ]:
245.703

[ Flash Point ]:
161.4ºC

[ Exact Mass ]:
245.081863

[ PSA ]:
72.55000

[ LogP ]:
2.32740

[ Index of Refraction ]:
-6.5 ° (C=2, H2O)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2580000

CHEMICAL NAME :: Tyrosine, ethyl ester, hydrochloride, L-

CAS REGISTRY NUMBER :: 4089-07-0

LAST UPDATED :: 198903

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N-O3.Cl-H

MOLECULAR WEIGHT :: 245.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,474,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,474,1987

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
YP2580000

[ Packaging Group ]:
III

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Transverse dephasing optimised NMR spectroscopy in solids: natural-abundance 13C correlation spectra.

ChemPhysChem 5(6) , 869-75, (2004)

Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine.

Free Radic. Res. 40 , 1-9, (2006)

Alzheimer's disease (AD) is characterised by the formation of amyloid deposits composed primarily of the amyloid beta-peptide (Abeta). This peptide has been shown to bind redox active metals ions such...

Dimorphism of the prodrug L-tyrosine ethyl ester: pressure-temperature state diagram and crystal structure of phase II.

J. Pharm. Sci. 100 , 4774-4782, (2011)

Polymorphism is important in the field of solid-state behavior of drug molecules because of the continuous drive for complete control over drug properties. By comparing different structures of a serie...