[Asu1,6-Arg8]Vasopressin

Names

[ CAS No. ]:
40944-53-4

[ Name ]:
[Asu1,6-Arg8]Vasopressin

[Synonym ]:
TYR-PHE-GLN-ASN-ASU-PRO-ARG-GLY-NH2
DEAMINO-DICARBA-ARGININE-VASOPRESSIN
Deamino-dicarba-Arg8-vasopressin

Biological Activity

[Description]:

[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[In Vitro]

[Asu1,6-Arg8]Vasopressin (100 nM; 0-240 分钟) 使 CRF 对培养的大鼠垂体前叶细胞 ACTH释放和循环 AMP 积累的刺激作用增加2倍。[Asu1,6-Arg8]Vasopressin 单独对腺垂体细胞中的循环AMP积累在任何时间间隔都没有影响[1]。

[References]

[1]. V Giguere, et al. Vasopressin potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture. Endocrinology. 1982 Nov;111(5):1752-4.  

[2]. I Pávó, et al. Differential inactivation of vasopressin receptor subtypes in isolated membranes and intact cells by N-ethylmaleimide. FEBS Lett. 1990 Oct 15;272(1-2):205-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C48H68N14O12

[ Molecular Weight ]:
1033.14000

[ Exact Mass ]:
1032.51000

[ PSA ]:
435.41000

[ LogP ]:
1.70250

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20

[ Safety Phrases ]:
36

Related Compounds