uridine triacetate

Names

[ Name ]:
uridine triacetate

[Synonym ]:
2',3',5-TRI-ACETYLURIDINE
EINECS 223-881-5
Vistogard
Uridine 2',3',5'-triacetate
2',3',5'-Tri-O-acetyl-rU
2’,3’,5’-Triacetyluridine
Uridine, 2',3',5'-triacetate
2`,3`,5`-Tracetyluridine
TAU
2',3',5'-Tri-O-acety
Tri-O-acetyl uridine
2',3',5'-Tri0acetyluridine
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
2',3',5'-Tri-O-acetyluridine
UNII-2WP61F175M
2',3',5'-Triacetyluridine
O2',O3',O5'-triacetyl-uridine
uridine triacetate
Xuriden
2',3',5'-O-triacetyluridine
2`,3`,5`-Triacetyluridine
2',3',5'-trioacetyluridine
MFCD00023795
Vistonuridine

Biological Activity

[Description]:

Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[References]

[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356.

[2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
124-134ºC

[ Molecular Formula ]:
C₁₅H₁₈N₂O₉

[ Molecular Weight ]:
370.311

[ Exact Mass ]:
370.101227

[ PSA ]:
142.99000

[ LogP ]:
-0.11

[ Index of Refraction ]:
1.552

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Evaluation of molecularly imprinted polymers using 2',3',5'-tri-O-acyluridines as templates for pyrimidine nucleoside recognition.

Anal. Bioanal. Chem 406(25) , 6275-84, (2014)

In this paper, we describe the synthesis and evaluation of molecularly imprinted polymers (MIPs), prepared using 2',3',5'-tri-O-acyluridines as 'dummy' templates, for the selective recognition of urid...