TIC10 Analogue

Names

[ Name ]:
TIC10 Analogue

[Synonym ]:
Imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one, 2,6,7,8,9,10-hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)-
Potent Akt/ERK inhibitor
7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one
7-Benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one
TIC10 - Isomer
TIC10 isomer

Biological Activity

[Description]:

TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

TRAIL (TNF related apoptosis inducing ligand) is a cytokine that kills cancer cells but shows no toxicity against normal cells. Active pharmaceutical ingredient TIC-10 (TRAIL inducing compound 10) (Compound 3a), is an anticancer drug first reported in a 1973 patent. The structure of TIC10 3a had been mis-assigned as TIC10 isomer (Compound 3b) in the initial patent. Subsequent synthesis of the originally reported structure by an alternate route shows TIC10 isomer (Compound 3b) does not possess the reported biological activity of inducing TRIAL expression[1].

[References]

[1]. Xin D, et al. Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ andEmpirically Derived Systematic Error Correction Terms: A Computational Small MoleculeStructure Elucidation Method. J Org Chem. 2017 May 19;82(10):5135-5145.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
559.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₆N₄O

[ Molecular Weight ]:
386.489

[ Flash Point ]:
292.3±32.9 °C

[ Exact Mass ]:
386.210663

[ PSA ]:
42.53000

[ LogP ]:
3.19

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.672

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble2mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL.

Angew. Chem. Int. Ed. Engl. , doi:10.1002/anie.201402133, (2014)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an immunosurveillance cytokine that kills cancer cells but demonstrates little toxicity against normal cells. While investigati...