CTP Inhibitor

Names

[ Name ]:
CTP Inhibitor

[Synonym ]:
4-Chloro-3-[[(3-nitrophenyl)amino]sulfonyl]-benzoic acid
4-Chloro-3-(3-nitro-phenylsulfamoyl)-benzoic acid
CTP Inhibitor

Biological Activity

[Description]:

CTP inhibitor is a potent and selective CTP inhibitor. CTP inhibitor inhibits the plasma membrane citrate transporter (PMCT)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

CTP[1]

[References]

[1]. Sun J, et al. Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol Cell Pharmacol. 2010; 2(3):101-110.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₉ClN₂O₆S

[ Molecular Weight ]:
356.73800

[ Exact Mass ]:
355.98700

[ PSA ]:
137.67000

[ LogP ]:
4.42420

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis.

Mol. Cell. Pharmacol. 2(3) , 101-110, (2010)

Cytoplasmic citrate is the prime carbon source for fatty acid, triacylglycerol, and cholesterol biosyntheses, and also regulates glucose metabolism via its allosteric inhibition of phosphofructokinase...

Targeting mitochondrial citrate transport in breast cancer cell lines.

Anticancer Agents Med. Chem. 15(3) , 374-81, (2015)

Lipogenesis is considered to be a very important aspect of cancer metabolism and targeting de novo lipid synthesis or related pathways are among novel approaches to treat cancer. Many targets of the p...

Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus.

Chromosoma 117(6) , 553-67, (2008)

To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and sub...