Penicillin G benzathine tetrahydrate

Names

[ Name ]:
Penicillin G benzathine tetrahydrate

[Synonym ]:
Penicillin G Benzathine Tetrahydrate
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsäure--N,N'-dibenzylethan-1,2-diamin(2:1)tetrahydrat
acide (2S,5R,6R)-3,3-diméthyl-7-oxo-6-[(phénylacétyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylique - N,N'-dibenzyléthane-1,2-diamine (2:1) tétrahydrate
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - N,N'-dibenzyl-1,2-ethanediamine hydrate (2:1:4)
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, (2S,5R,6R)-, compd. with N,N'-bis(phenylmethyl)-1,2-ethanediamine, hydrate (2:1:4)
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-, (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine, hydrate (2:1:4)
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - N,N'-dibenzylethane-1,2-diamine (2:1) tetrahydrate

Biological Activity

[Description]:

Penicillin G benzathine tetrahydrate (Benzathine benzylpenicillin tetrahydrate) is an antibiotic against many bacterial infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Penicillin G benzathine tetrahydrate displays activity and antibacterial effect in CD-I mice infected with Staphylococcus aureus Smith[2].

[References]

[1]. Bowen AC, et al. Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Lancet. 2014 Dec 13;384(9960):2132-40.

[2]. J A Yurchenco, et al. Substituted Penicillin Amides. Duration of Antibacterial Activity (Depot Effect) in Experimental Infections in Mice. Chemotherapy . 1972;17(6):405-15.

Chemical & Physical Properties

[ Boiling Point ]:
1299.8ºC at 760 mmHg

[ Melting Point ]:
123-124°C

[ Molecular Formula ]:
C₄₈H₆₄N₆O₁₂S₂

[ Molecular Weight ]:
981.185

[ Flash Point ]:
739.9ºC

[ Exact Mass ]:
980.402344

[ PSA ]:
285.00000

[ LogP ]:
5.46980

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
42/43

[ Safety Phrases ]:
22-36/37-45-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2941109900

Customs

[ HS Code ]: 2941109900