ODQ

Names

[ Name ]:
ODQ

[Synonym ]:
[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Lopac-O-3636
T B566 BNVON HNJ
1H-[1,2,4]oxadiazolol[4,3,-a]quinoxalin-1-one
Tocris-0880
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
MFCD00792620
1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
ODQ
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-1-ine

Biological Activity

[Description]:

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[In Vitro]

At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1].

[In Vivo]

ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2]. Animal Model: Anesthetized, male Wistar rats[2] Dosage: 2 mg/kg Administration: I.p. Result: Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.

[References]

[1]. Ronald Fiscus, et al. ODQ, an inhibitor of soluble guanylyl cyclase (nitric oxide-activated enzyme), enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. Cancer Res May 1 2007 (67) (9 Supplement) LB-43.

[2]. Zacharowski K, et al. The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med. 2001;29(8):1599-1608.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
321.3±25.0 °C at 760 mmHg

[ Melting Point ]:
160-170 °C

[ Molecular Formula ]:
C₉H₅N₃O₂

[ Molecular Weight ]:
187.155

[ Flash Point ]:
148.1±23.2 °C

[ Exact Mass ]:
187.038177

[ PSA ]:
60.40000

[ LogP ]:
0.28

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.781

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 1.2 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in ant...

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J. Cardiovasc. Pharmacol. 65(1) , 1-7, (2015)

Mechanical stress can induce cardiac hypertrophy and autophagy. Recently, it has been reported that nitric oxide donors inhibited autophagy in human chondrocytes. Therefore, the effect of isosorbide d...

ODQ