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Turkesterone

Names

[ CAS No. ]:
41451-87-0

[ Name ]:
Turkesterone

[Synonym ]:
TURKESTERONE(SH)
(2β,3β,5β,11α,22R)-2,3,11,14,20,22,25-Heptahydroxycholest-7-en-6-one
(2beta,3beta,5beta,11alpha,22R)-2,3,11,14,20,22,25-Heptahydroxycholest-7-en-6-one
Cholest-7-en-6-one, 2,3,11,14,20,22,25-heptahydroxy-, (2β,3β,5β,11α,22R)-

Biological Activity

[Description]:

Turkesterone, isolated from Ajuga turkestanica, is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

Ecdysteroid receptor (EcR)[1]


[In Vitro]

The ability of Turkesterone to displace [3H]ponA from in vitro-expressed DmEcR/DmUSP receptor complex is assessed. The EC50 is 0.8 μM in the BII bioassay, Ki value is 90 nM in the receptor assay[1].

[References]

[1]. Dinan L, et al. Synthesis and biological activities of turkesterone 11alpha-acyl derivatives. J Insect Sci. 2003;3:6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
740.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H44O8

[ Molecular Weight ]:
496.634

[ Flash Point ]:
415.3±29.4 °C

[ Exact Mass ]:
496.303619

[ PSA ]:
158.68000

[ LogP ]:
-1.53

[ Vapour Pressure ]:
0.0±5.5 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
2-8°C

Related Compounds