GPR30 agonist-1

Names

[ CAS No. ]:
415919-74-3

[ Name ]:
GPR30 agonist-1

Biological Activity

[Description]:

GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

[In Vivo]

GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1].

[References]

[1]. Brad R S Broughton, et al. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₇BrFNO

[ Molecular Weight ]:
374.25

GPR30 agonist-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds