(S)-(-)-PROPRANOLOL HYDROCHLORIDE

Names

[ Name ]:
(S)-(-)-PROPRANOLOL HYDROCHLORIDE

[Synonym ]:
dl-propranololHClbp
PROPRANOLOL HCL
dl-propranolol hcl
dl-propranololhydrochloridebp
PENTAPROPANOLOLHYDROCHLORIDE
Sazetidine A dihydrochloride
DL-PROPRANOLOL HYDROCHLORIDE
EINECS 224-096-0
PROPANOLOL HYDROCHLORIDE
L-Propranololhydrochlorid
MFCD00064547

Biological Activity

[Description]:

(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[Target]

log Kd: -8.16 (β1-adrenergic receptor) log Kd: -9.08 (β2-adrenergic receptor) log Kd: -6.93 (β3-adrenergic receptor)[1]

[References]

[1]. Jillian G Baker , et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.

Chemical & Physical Properties

[ Boiling Point ]:
434.9ºC at 760mmHg

[ Melting Point ]:
193-195ºC(lit.)

[ Molecular Formula ]:
C₁₆H₂₂ClNO₂

[ Molecular Weight ]:
295.80400

[ Flash Point ]:
216.8ºC

[ Exact Mass ]:
295.13400

[ PSA ]:
41.49000

[ LogP ]:
3.77040

[ Appearance of Characters ]:
powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 10 mg/mL

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2906199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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