4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

Names

[ Name ]:
4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

[Synonym ]:
4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine
3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE
Diethylene Glycol Bis(3-aMinopropyl) Ether
EINECS 224-207-2
MFCD00059850
3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine)
1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-
3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine)
Bis[2-(3-aminopropoxy)ethyl] Ether

Biological Activity

[Description]:

PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
310.6±0.0 °C at 760 mmHg

[ Melting Point ]:
-32 °C

[ Molecular Formula ]:
C₁₀H₂₄N₂O₃

[ Molecular Weight ]:
220.309

[ Flash Point ]:
148.0±17.4 °C

[ Exact Mass ]:
220.178696

[ PSA ]:
79.73000

[ LogP ]:
-1.51

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.464

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ID6475000

CHEMICAL NAME :: Diethylene glycol, di(3-aminopropyl) ether

CAS REGISTRY NUMBER :: 4246-51-9

BEILSTEIN REFERENCE NO. :: 1760709

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H24-N2-O3

MOLECULAR WEIGHT :: 220.36

WISWESSER LINE NOTATION :: Z3O2O2O3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1067 No. of Facilities: 307 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 13486 (estimated) No. of Female Employees: 3955 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
ID6475000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

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J. Chromatogr. A. 1359 , 84-90, (2014)

A new approach for proteome-wide profiling drug binding proteins by using monolithic capillary affinity chromatography in combination with HPLC-MS/MS is reported. Two immunosuppresive drugs, namely FK...

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Chemistry 21 , 10729-40, (2015)

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Hollow Mesoporous Silica Nanocarriers with Multifunctional Capping Agents for In Vivo Cancer Imaging and Therapy.

Small 12 , 360-70, (2016)

Efficient drug loading and selectivity in drug delivery are two key features of a good drug-carrier design. Here we report on such a drug carrier formed by using hollow mesoporous silica nanoparticles...