Bis-Tos-PEG6

Names

[ Name ]:
Bis-Tos-PEG6

[Synonym ]:
PEG7-bis-Tos
Hexaethylene glycol ditosylate
O,O'-ditosyl-3,6,9,12,15-pentaoxaheptadecane-1,17-diol
3,6,9,12,15-pentaoxaheptadecane-1,17-diol ditosylate
HEG ditosylate
3,6,9,12,15-pentaoxa-1,17-heptadecyl di-p-toluenesulfonate

Biological Activity

[Description]:

Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
687.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₈O₁₁S₂

[ Molecular Weight ]:
590.70300

[ Flash Point ]:
369.5ºC

[ Exact Mass ]:
590.18600

[ PSA ]:
149.65000

[ LogP ]:
4.65880

[ Index of Refraction ]:
1.525

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%