Didesethyl Chloroquine

Names

[ Name ]:
Didesethyl Chloroquine

[Synonym ]:
4-N-(7-chloroquinolin-4-yl)pentane-1,4-diamine

Biological Activity

[Description]:

Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial drug Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Biot C, et al. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg Med Chem. 1999 Dec;7(12):2843-7.

[2]. Essien EE, et al. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J Pharm Pharmacol. 1986 Jul;38(7):543-6.

Chemical & Physical Properties

[ Density]:
1.208g/cm3

[ Boiling Point ]:
441.4ºC at 760 mmHg

[ Melting Point ]:
139-141ºC

[ Molecular Formula ]:
C₁₄H₁₈ClN₃

[ Molecular Weight ]:
263.76600

[ Flash Point ]:
220.8ºC

[ Exact Mass ]:
263.11900

[ PSA ]:
50.94000

[ LogP ]:
4.20080

[ Index of Refraction ]:
1.64

[ Storage condition ]:
20°C

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%