SMI481

Names

[ CAS No. ]:
432020-20-7

[ Name ]:
SMI481

[Synonym ]:
(4-Chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]methanone
Methanone, (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-
MFCD03575351

Biological Activity

[Description]:

NPPM 6748-481 is a selective inhibitor of the yeast phosphatidylinositol transfer protein (PITP) Sec14[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Nile, Aaron H.; Tripathi, Ashutosh; Yuan, Peihua; et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nature Chemical Biology (2014), 10(1), 76-84.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
543.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₅ClFN₃O₃

[ Molecular Weight ]:
363.771

[ Flash Point ]:
282.4±30.1 °C

[ Exact Mass ]:
363.078583

[ LogP ]:
2.46

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.625

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

SMI481

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds