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ReAsH-EDT2

Names

[ CAS No. ]:
438226-89-2

[ Name ]:
ReAsH-EDT2

[Synonym ]:
Lumio Red
ReAsH-EDT2
3H-Phenoxazin-3-one,4,6-di-1,3,2-dithiarsolan-2-yl-7-hydroxy
4,6-Di-1,3,2-dithiarsolan-2-yl-7-hydroxy-3H-phenoxazin-3-one

Biological Activity

[Description]:

ReAsH-EDT2 is a red fluorescent dye that marks proteins. ReAsH-EDT2 is a membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences which allows the protein to be imaged. ReAsH-EDT2 can be used for protein localization and trafficking. (λex=530 nm, λem=592 nm)[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

ReAsH-EDT2 tags with GyrB.FGFR1KD.TC can appear with red fluorescence.

[References]

[1]. Adams SR, et, al. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008;3(9):1527-34.

[2]. Perdios L, et, al. Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. Adv Biol Regul. 2016 Jan;60:6-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13As2NO3S4

[ Molecular Weight ]:
545.38300

[ Exact Mass ]:
544.82100

[ PSA ]:
164.53000

[ LogP ]:
2.34880

Related Compounds