4-Epianhydrotetracycline hydrochloride

Names

[ Name ]:
4-Epianhydrotetracycline hydrochloride

[Synonym ]:
4-Epianhydrotetracycline HCl
MFCD00151455
4-Epi-Anhydrotetracycline Hydrochloride
4-Epianhydrotetracycline hydrochloride

Biological Activity

[Description]:

4-Epianhydrotetracycline hydrochloride is a degradation product of the antibiotic tetracycline. 4-Epianhydrotetracycline hydrochloride is active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli (MIC50s = 0.75-16 mg/L).

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Chemical & Physical Properties

[ Boiling Point ]:
618.6ºC at 760 mmHg

[ Melting Point ]:
220ºC

[ Molecular Formula ]:
C₂₂H₂₃ClN₂O₇

[ Molecular Weight ]:
462.88000

[ Flash Point ]:
327.9ºC

[ Exact Mass ]:
462.11900

[ PSA ]:
161.39000

[ LogP ]:
1.95810

[ Appearance of Characters ]:
Powder | Orange

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
63-36-22

[ Safety Phrases ]:
36/37/39-26

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012)

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate...

Development of a repressible mycobacterial promoter system based on two transcriptional repressors.

Nucleic Acids Res. 38(12) , e134, (2010)

Tightly regulated gene expression systems represent invaluable tools for studying gene function and for the validation of drug targets in bacteria. While several regulated bacterial promoters have bee...

[A precise equilibrium equation for four steps of binding between TBP and TATA-box allows for the prediction of phenotypical expression upon mutation].

Biofizika 55(3) , 400-14, (2010)

Among the main events of transcription initiation of TATA-containing genes in eukayotes are the recognition and binding of the TATA-box by the TATA-binding protein (TBP) to start the preinitiation com...