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ML148

Names

[ CAS No. ]:
451496-96-1

[ Name ]:
ML148

[Synonym ]:
[1-(3-Methylphenyl)-1H-benzimidazol-5-yl](1-piperidinyl)methanone
Methanone, [1-(3-methylphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl-
[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-benzimidazole

Biological Activity

[Description]:

ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 15-PGDH
Research Areas >> Inflammation/Immunology

[Target]

IC50: 56 nM (15-PGDH)[1]


[In Vitro]

ML148 (compound 13) shows selectivity with IC50s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively[1]. ML148 (10, 20 nM) decrease Vmax by 25% and reduces the apparent Km by half at a concentration of 10 nM[1].

[References]

[1]. Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5(11):e13719.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
543.4±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H21N3O

[ Molecular Weight ]:
319.40

[ Flash Point ]:
282.5±30.7 °C

[ Exact Mass ]:
319.168457

[ LogP ]:
3.31

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
-20°C

Related Compounds