Human β-defensin-1

Names

[ CAS No. ]:
452274-53-2

[ Name ]:
Human β-defensin-1

Biological Activity

[Description]:

Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: skin-antimicrobial peptide (SAP)[1]


[References]

[1]. E V Valore, et al. Human beta-defensin-1: An Antimicrobial Peptide of Urogenital Tissues.J Clin Invest. 1998 Apr 15;101(8):1633-42.

[2]. Judith Raschig, et al. Ubiquitously Expressed Human Beta Defensin 1 (hBD1) Forms Bacteria-Entrapping Nets in a Redox Dependent Mode of Action. PLoS Pathog. 2017 Mar 21;13(3):e1006261.

Chemical & Physical Properties

[ Molecular Formula ]:
C167H256N48O50S6

[ Molecular Weight ]:
3928.53

Related Compounds