Thalidomide-benzo

Names

[ Name ]:
Thalidomide-benzo

Biological Activity

[Description]:

Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂N₂O₄

[ Molecular Weight ]:
308.29

[ Storage condition ]:
2-8°C

Thalidomide-benzo

Names

Biological Activity

Chemical & Physical Properties

Related Compounds