Arylomycin A2

Arylomycin A2, an Antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

Arylomycin A2 exhibits very potent antibacterial activity against free-living S. epidermidis cells. The MIC values against planktonic S. epidermidis 1457 and RP62A are 0.235 μg/mL and 0.058 μg/mL for Arylomycin A2, respectively. Arylomycin A2 shows the antibacterial effect towards S. epidermidis biofilms, and reduces biofilm formation markedly[2].

[1]. Mark Paetzel, et al. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. J Biol Chem. 2004 Jul 16;279(29):30781-90.  

[2]. Katrijn Bockstael, et al. Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis. Microbiology (Reading). 2009 Nov;155(Pt 11):3719-3729.