Neriifolin

Names

[ CAS No. ]:
466-07-9

[ Name ]:
Neriifolin

[Synonym ]:
NERIIFOLIN
17Beta-Neriifolin
xy)-14-hydroxy
digitoxigenin+thevetose

Biological Activity

[Description]:

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[In Vitro]

Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1].

[References]

[1]. Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237.

[2]. Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.

Chemical & Physical Properties

[ Density]:
1.274g/cm3

[ Boiling Point ]:
700.079ºC at 760 mmHg

[ Melting Point ]:
218-225ºC

[ Molecular Formula ]:
C₃₀H₄₆O₈

[ Molecular Weight ]:
534.68100

[ Flash Point ]:
224.862ºC

[ Exact Mass ]:
534.31900

[ PSA ]:
114.68000

[ LogP ]:
3.11020

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.581

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
26/27/28

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
FH4906100