Carbamic acid,N-(phenylmethyl)-, 2-hydroxyethyl ester

Names

[ CAS No. ]:
4663-83-6

[ Name ]:
Carbamic acid,N-(phenylmethyl)-, 2-hydroxyethyl ester

[Synonym ]:
AC-601
Buramate
Hyamate
Buramat
2-Benzylcarbamoyloxy-aethanol
2-Hydroxyethyl benzylcarbamate

Biological Activity

[Description]:

Buramate exhibits neuroprotective and anticonvulsant activities.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Chemical & Physical Properties

[ Density]:
1.182 g/cm3

[ Boiling Point ]:
375.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₃NO₃

[ Molecular Weight ]:
195.21500

[ Flash Point ]:
181.1ºC

[ Exact Mass ]:
195.09000

[ PSA ]:
58.56000

[ LogP ]:
1.29600

[ Index of Refraction ]:
1.542

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EY8747000

CHEMICAL NAME :: Carbamic acid, benzyl-, 2-hydroxyethyl ester

CAS REGISTRY NUMBER :: 4663-83-6

BEILSTEIN REFERENCE NO. :: 2838813

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H13-N-O3

MOLECULAR WEIGHT :: 195.24

WISWESSER LINE NOTATION :: Q2OVM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 127,220,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 9,390,1951

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%