Butane-1,4-diyldiphosphonic acid

Names

[ Name ]:
Butane-1,4-diyldiphosphonic acid

[Synonym ]:
1,2-butylenediphosphonic acid
1,4-Diphosphonobutane
1,4-butylene-diphosphonic acid
Butane-1,4-diphosphonic acid
1,4-Butanediphosphonic acid
MFCD01631212
butane-1,4-diyldiphosphonic acid
1,4-butylenediphosphonic avid

Biological Activity

[Description]:

Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Boiling Point ]:
544.4ºC at 760 mmHg

[ Melting Point ]:
219-221ºC

[ Molecular Formula ]:
C₄H₁₂O₆P₂

[ Molecular Weight ]:
218.08200

[ Flash Point ]:
283.1ºC

[ Exact Mass ]:
218.01100

[ PSA ]:
134.68000

[ LogP ]:
0.12200

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S25-S36/37/39-S45