Lactosylceramides (bovine buttermilk)

Names

[ Name ]:
Lactosylceramides (bovine buttermilk)

[Synonym ]:
CDH
MFCD00133445
Lactocerebrosides from bovine brain

Biological Activity

[Description]:

Lactosylceramide (LacCer) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
1001.4ºC at 760 mmHg

[ Molecular Formula ]:
C₅₃H₁₀₁NO₁₃

[ Molecular Weight ]:
960.36800

[ Flash Point ]:
559.4ºC

[ Exact Mass ]:
959.72700

[ PSA ]:
227.86000

[ LogP ]:
8.53810

[ Index of Refraction ]:
1.538

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK1000000

CHEMICAL NAME :: Ceramide, 1-O-(4-O-beta-D-galactopyranosyl-beta-glucopyranosyl) -

CAS REGISTRY NUMBER :: 4682-48-8

LAST UPDATED :: 199212

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 100 umol/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 199,169,1992

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
FK1000000

Articles

Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomains and prevents lactosylceramide-dependent recognition.

Infect. Immun. 80(2) , 506-17, (2012)

Streptococcus suis type 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans. S. suis infects the host through the respiratory route, reaches the bloodstream, ...

Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells.

Oncol. Rep. 25(4) , 1161-7, (2011)

The selection pressure for resistance to chemotherapy is accompanied by the enhanced expression of ABC proteins and increased cellular glycosphingolipid content. Thus, a possible connection between gl...

Different mechanisms are involved in apoptosis induced by melanoma gangliosides on human monocyte-derived dendritic cells.

Glycobiology 19(6) , 576-82, (2009)

Tumor escape is linked to multiple mechanisms, notably the liberation, by tumor cells, of soluble factors that inhibit the function of dendritic cells (DC). We have shown that melanoma gangliosides im...