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24-Methylene cycloartanyl ferulate

Names

[ CAS No. ]:
469-36-3

[ Name ]:
24-Methylene cycloartanyl ferulate

[Synonym ]:
24-Methylenecycloartanyl Ferulate
3-O-feruloylquinic acid
Oryzanol C
3-Feruloylchinasaeure
3-feruloylquinic acid
3-O-ferulyl-24-methylenecycloartanol
5-O-feruloyl quinic acid
24-methylenecycloartanol ferulate
24-methylcycloartanyl ferulate
24-methylene cycloartanyl ferulate
(3β,9β)-24-Methylene-9,19-cyclolanostan-3-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
(3β,9β)-24-methylidene-9,19-cyclolanostan-3-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
24-methylenecycloartanol trans-ferulate
2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (3β,9β)-24-methylene-9,19-cyclolanostan-3-yl ester, (2E)-
5-feruloylquinic acid

Biological Activity

[Description]:

24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt1:33.3 μM (EC50)


[References]

[1]. Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):574-9.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
668.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C41H60O4

[ Molecular Weight ]:
616.913

[ Flash Point ]:
193.5±20.8 °C

[ Exact Mass ]:
616.449158

[ PSA ]:
55.76000

[ LogP ]:
13.20

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.564

Related Compounds