Antibacterial agent 121

Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

Antibacterial agent 121 (0.2-200 µM; 24 h) inhibits M. tuberculosis H37Rv growth in bacterial culture[1]. Antibacterial agent 121 (0-200 µM; 24 h) inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 4.1 µM[1]. Antibacterial agent 121 (6.25-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages[1]. Antibacterial agent 121 (25-100 µM, 4 d) inhibits M. tuberculosis M299 with an MIC50 value of 24.8 µM[1]. Cell Viability Assay[1] Cell Line: M. tuberculosis H37Rv Concentration: 0.2-200 µM Incubation Time: 24 hours Result: Inhibited Mtb H37Rv growth with MIC50 of 8.6 µM. Cell Viability Assay[1] Cell Line: RAW 264.7 macrophages and J774A.1 macrophages Concentration: 6.25-200 µM Incubation Time: 24 hours Result: Showed IC50 values of 15.3 µM and 28.4 µM for TNF-α and IL-1β production, respectively.

[1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.