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FAUC-365

Names

[ CAS No. ]:
474432-66-1

[ Name ]:
FAUC-365

[Synonym ]:
N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-1-benzothiophene-2-carboxamide
N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-1-benzothiophene-2-carboxamide
Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-

Biological Activity

[Description]:

FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[References]

[1]. Philip Seeman, et al. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse. 2006 Sep 1;60(3):205-11.

[2]. Carsten Hocke, et al. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3963-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
680.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H25Cl2N3OS

[ Molecular Weight ]:
462.435

[ Flash Point ]:
365.2±31.5 °C

[ Exact Mass ]:
461.109528

[ LogP ]:
7.14

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.638

Related Compounds