Isotetrandrine
Names
[ CAS No. ]:
477-57-6
[ Name ]:
Isotetrandrine
[Synonym ]:
O,O'-Dimethylobamegine
isotetrandine
O-Methylberbamine
O,O'-Dimethylstepholine
6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Isosinomenine A
6,7,12,6'-tetramethoxy-2,2'-dimethyl-berbamane
1R,1'S isotetrandrine
1-isotetrandrine
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
710.5±60.0 °C at 760 mmHg
[ Melting Point ]:
180-182ºC
[ Molecular Formula ]:
C38H42N2O6
[ Molecular Weight ]:
622.750
[ Flash Point ]:
175.8±30.1 °C
[ Exact Mass ]:
622.304260
[ PSA ]:
61.86000
[ LogP ]:
3.55
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.586
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NX7285000
- CHEMICAL NAME :
- 1-Isotetrandrine
- CAS REGISTRY NUMBER :
- 477-57-6
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C38-H42-N2-O6
- MOLECULAR WEIGHT :
- 622.82
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(5),176S,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
Safety Information
[ Hazard Codes ]:
Xi