S-Phenylmercapturic Acid

Names

[ Name ]:
S-Phenylmercapturic Acid

[Synonym ]:
s-phenylmercapturic acid

Biological Activity

[Description]:

S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Peter B Farmer, et al. The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene. Chem Biol Interact. 2005 May 30;153-154:97-102.

Chemical & Physical Properties

[ Boiling Point ]:
494.5ºC at 760 mmHg

[ Melting Point ]:
110-112ºC

[ Molecular Formula ]:
C₁₀H₁₃NO₂S

[ Molecular Weight ]:
211.28100

[ Flash Point ]:
252.9ºC

[ Exact Mass ]:
211.06700

[ PSA ]:
74.63000

[ LogP ]:
1.84220

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Influence of genetic polymorphism on t,t-MA/S-PMA ratio in 301 benzene exposed subjects.

Toxicol. Lett. 231(2) , 205-12, (2014)

This study investigated the effect of polymorphic genes GSTT1, GSTM1, GSTA1, EHPX1, NQO1, CYP2E1, CYP1A and MPO on the urinary concentrations and ratio (R) of the benzene metabolites trans,trans-mucon...

Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: state of the art.

Toxicol. Lett. 231(2) , 194-204, (2014)

Current levels of occupational exposure to benzene, a genotoxic human carcinogen, in Western countries are reduced by two-three orders of magnitude (from ppm to ppb) as compared to the past. However, ...

Urinary trans, trans-muconic acid and S-phenylmercapturic acid are indicative of exposure to urban benzene pollution during childhood.

Sci. Total Environ. 435-436 , 115-23, (2012)

The aims of the study were to evaluate the feasibility of urinary trans, trans-muconic acid (u-t,t-MA) and urinary S-phenylmercapturic acid (u-SPMA) as markers of exposure to urban benzene pollution f...