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Calcium-Sensing Receptor Antagonists I

Names

[ CAS No. ]:
478963-79-0

[ Name ]:
Calcium-Sensing Receptor Antagonists I

[Synonym ]:
CS-0307
1-(1-METHYLETHYL)-4-[4-(1-METHYLETHYL)PHENYL]-6-(2-PROPYN-1-YLOXY)-2(1H)-QUINAZOLINONE
Calcium-Sensing Receptor Antagonists I

Biological Activity

[Description]:

Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. IC50 value:Target: CaSRCalcium-Sensing Receptor Antagonists I is useful for osteoporosis and other bone conditions

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CaSR
Research Areas >> Others

[References]

[1]. Widler, Leo et al. 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists.Journal of Medicinal Chemistry(2010),53(5), 2250-2263.


[Related Small Molecules]

NPS-2143 | Evocalcet | Strontium Ranelate | SB-423562

Chemical & Physical Properties

[ Density]:
1.085g/cm3

[ Boiling Point ]:
510.1ºC at 760 mmHg

[ Molecular Formula ]:
C23H24N2O2

[ Molecular Weight ]:
360.44900

[ Flash Point ]:
262.299ºC

[ Exact Mass ]:
360.18400

[ PSA ]:
44.12000

[ LogP ]:
4.77980

[ Index of Refraction ]:
1.572

[ Storage condition ]:
2-8℃

Related Compounds