5-Valine-angiotensin I

Names

[ CAS No. ]:
484-43-5

[ Name ]:
5-Valine-angiotensin I

[Synonym ]:
[Val5]-Angiotensin I bovine
Asp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu-OH
L-Asp-L-Arg-L-Val-L-Tyr-L-Val-L-His-L-Pro-L-Phe-L-His-L-Leu-OH

Biological Activity

[Description]:

5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

5-Valine-angiotensin I shows myotropic effect (muscle contraction) on isolated rat colon after nonspecific desensitization of receptors with acetylcholine[2].

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Molecular Formula ]:
C₆₁H₈₇N₁₇O₁₄

[ Molecular Weight ]:
1282.45000

[ Exact Mass ]:
1281.66000

[ PSA ]:
493.22000

[ LogP ]:
3.44270

[ Index of Refraction ]:
1.671

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Renal responses to AT1 receptor blockade.

Am. J. Hypertens. 13 , 45S-54S, (2000)

Because of the importance of the renin-angiotensin system in the pathophysiology of hypertension and in mediating associated alterations in renal function, angiotensin II (Ang II) AT1 receptor blocker...

Purification and identification of endogenous anti-opioid substances from bovine brain.

Biochem. Biophys. Res. Commun. 126(1) , 587-93, (1985)

Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpe...

Determination of renin activity in human plasma by column-switching high-performance liquid chromatography with fluorescence detection. Miyazaki T, Kai M, Ohkura Y.

J. Chromatogr. A. 490 , 43-51, (1989)