Vasicinone

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1]. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1]. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1~30 µM Incubation Time: 24 hours Result: Significantly reversed the paraquat-induced reduction in cell viability. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Dose-dependently reduced the percentage of apoptotic cells.

[1]. Ju DT, et al. Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model. Nutrients. 2019;11(7):1655. Published 2019 Jul 19.