Citropten

Names

[ CAS No. ]:
487-06-9

[ Name ]:
Citropten

[Synonym ]:
5,7-Dimethoxy-2H-1-benzopyran-2-one
MFCD00006870
5,7-dimethoxy-coumarin
EINECS 207-646-4
Limettin
Citropten
5,7-Dimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 5,7-dimethoxy-
5,7-dimethoxychromen-2-one
5,7-Dimethoxycoumarin
5,7-Dimethoxy-chromen-2-one

Biological Activity

[Description]:

Citropten (5,7-Dimethoxycoumarin) is a coumarin isolated from bergamot oil. Citropten (5,7-Dimethoxycoumarin) has an antiproliferative activity against A2058 human melanoma cell line[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Makki S, et al. High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans. J Chromatogr. 1991 Feb 15;563(2):407-13.

[2]. Wolny D, et al. Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells. Acta Pol Pharm. 2014 Nov-Dec;71(6):1056-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
388.1±42.0 °C at 760 mmHg

[ Melting Point ]:
146-149 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₀O₄

[ Molecular Weight ]:
206.195

[ Flash Point ]:
176.3±27.9 °C

[ Exact Mass ]:
206.057907

[ PSA ]:
48.67000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.557

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6530000

CHEMICAL NAME :: Coumarin, 5,7-dimethoxy-

CAS REGISTRY NUMBER :: 487-06-9

BEILSTEIN REFERENCE NO. :: 0187066

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H10-O4

MOLECULAR WEIGHT :: 206.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 42,333,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GN6530000

Precursor & DownStream

Precursor

DownStream

Articles

Simultaneous determination of 16 phenolic constituents in Spatholobi Caulis by high performance liquid chromatography/electrospray ionization triple quadrupole mass spectrometry.

J. Pharm. Biomed. Anal. 102 , 110-8, (2014)

Spatholobi Caulis, the vine stem of Spatholobus suberectus Dunn, has been widely used in traditional Chinese and folk medicines for treatment of irregular menstruation, blood deficiency and rheumatalg...

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic Sci. Int. 249 , e7-11, (2015)

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly...

Relative photomutagenicity of furocoumarins and limettin in the hypoxanthine phosphoribosyl transferase assay in V79 cells.

Chem. Res. Toxicol. 22(9) , 1639-47, (2009)

Furocoumarins are phototoxic and photomutagenic natural plant constituents found in many medicinal plants and food items. Because plants contain mixtures of several furocoumarins, there is a need for ...