Propargyl-PEG1-Boc

Names

[ CAS No. ]:
488150-84-1

[ Name ]:
Propargyl-PEG1-Boc

[Synonym ]:
PROPARGYL-PEG1-CH2CH2COOTBU

Biological Activity

[Description]:

Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
239.2±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆O₃

[ Molecular Weight ]:
184.232

[ Flash Point ]:
93.1±15.0 °C

[ Exact Mass ]:
184.109940

[ LogP ]:
1.97

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.443

Propargyl-PEG1-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds