Guaiol

Names

[ CAS No. ]:
489-86-1

[ Name ]:
Guaiol

[Synonym ]:
2-[(3S,5R,8S)-3,8-Dimethyl-1,2,3,4,5,6,7,8-octahydroazulen-5-yl]propan-2-ol
(-)-GUAIOL
Guai-1(5)-en-11-ol (8CI)
Guaiac alcohol
Champacol
Cuajol
Champaca camphor
Gualol
Guaiol
2-[(3S,5R,8S)-3,8-Dimethyl-1,2,3,4,5,6,7,8-octahydro-5-azulenyl]-2-propanol
Champaeol
[3S-(3a,5a,8a)]-1,2,3,4,5,6,7,8-Octahydro-a,a,3,8-tetramethyl-5-azulenemethanol
3,8-Dimethyl-5-(a-hydroxyisopropyl)-D9-octahydroazulene
5-Azulenemethanol, 1,2,3,4,5,6,7,8-octahydro-α,α,3,8-tetramethyl-, (3S,5R,8S)-

Biological Activity

[Description]:

Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Yang, Q, et al. (−)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Oncotarget. 2016 Sep 20;7(38):62585-62597.

[2]. Ali, A., Tabanca, et al. Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes J. Agric. Food Chem. 63(2), 447-456 (2015).

[3]. Liu, T, et al. Guaiol - a naturally occurring insecticidal sesquiterpene Nat. Prod. Commun. 8(10), 1353-1354 (2013).

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
288.0±0.0 °C at 760 mmHg

[ Melting Point ]:
91-93ºC(lit.)

[ Molecular Formula ]:
C₁₅H₂₆O

[ Molecular Weight ]:
222.37

[ Flash Point ]:
113.6±15.6 °C

[ Exact Mass ]:
222.198364

[ PSA ]:
20.23000

[ LogP ]:
4.81

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.503

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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In order to avoid both natural and artificial stone decay, mainly due to the interaction with atmospheric pollutants (both gases such as NOx and SO2 and particulate matter), polymeric materials have b...

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Effects of grind size when alkaline treating corn residue and impact of ratio of alkaline-treated residue and distillers grains on performance of finishing cattle.

J. Anim. Sci. 93 , 3613-22, (2015)

Two studies were conducted to optimize use of alkaline-treated corn stover and wheat straw and distillers grains as partial corn replacements. In Exp. 1, a finishing experiment used 30 pens (12 steers...