Fmoc-NH-PEG3-amide-CH2OCH2COOH

Names

[ Name ]:
Fmoc-NH-PEG3-amide-CH2OCH2COOH

[Synonym ]:
2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid

Biological Activity

[Description]:

Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.256g/cm3

[ Boiling Point ]:
794.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₄N₂O₉

[ Molecular Weight ]:
530.56700

[ Flash Point ]:
434.5ºC

[ Exact Mass ]:
530.22600

[ PSA ]:
141.65000

[ LogP ]:
2.57410

[ Index of Refraction ]:
1.558

[ Storage condition ]:
2-8°C

Fmoc-NH-PEG3-amide-CH2OCH2COOH

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds