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4-Quinazolinone

Names

[ CAS No. ]:
491-36-1

[ Name ]:
4-Quinazolinone

[Synonym ]:
MFCD00511302
Quinazolone,4
3,4-Dihydro-4-oxoquinazoline
QUINAZOLONE
T66 BVN EMJ
QUINAZOLIN-4-OL
4-oxo-3,4-dihydroquinazoline
T66 BVM ENJ
4-QUINAZOLINO
4(3H)-Quinazolinone
3,4-dihydroquinazolin-4-one
quinazolin-4(3H)-one
3H-quinazolinyl-4-one
quinazoline-4(3H)-one
4-QUINAZOLONE
4-Quinazolinol
T66 BN DNJ EQ
EINECS 207-735-8
4-Hydroxyquinazoline
Quinazolin-4-one
4(1H)-Quinazolinone
QUINAZOLINONE
4-HQN

Biological Activity

[Description]:

4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Cancer
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Research Areas >> Infection
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[References]

[1]. Jafari E, et al. Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities. Res Pharm Sci. 2016 Jan-Feb;11(1):1-14.

[2]. Hameed A, et al. Quinazoline and quinazolinone as important medicinal scaffolds: a comparative patent review (2011-2016). Expert Opin Ther Pat. 2018 Apr;28(4):281-297.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
324.8±15.0 °C at 760 mmHg

[ Melting Point ]:
216-219 °C(lit.)

[ Molecular Formula ]:
C8H6N2O

[ Molecular Weight ]:
146.146

[ Flash Point ]:
150.2±20.4 °C

[ Exact Mass ]:
146.048019

[ PSA ]:
45.75000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Storage condition ]:
Desiccate at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA2300000
CHEMICAL NAME :
4(3H)-Quinazolinone
CAS REGISTRY NUMBER :
491-36-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-N2-O
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION :
T66 BVM ENJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
609 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39-S22

[ WGK Germany ]:
3

[ RTECS ]:
VA2300000

[ HS Code ]:
29335995

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds