FAK-IN-10

Names

[ Name ]:
FAK-IN-10

[Synonym ]:
Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]-

Biological Activity

[Description]:

FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK

[References]

[1]. Zhang LR, et al. Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives. Bioorg Med Chem. 2012 Jun 1;20(11):3615-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₀BrN₃O₂S

[ Molecular Weight ]:
376.2278